Popular guidelines

Can clozapine cause sudden death?

Can clozapine cause sudden death?

Many cases of sudden death may be attributable to cardiac complications of clozapine, but other unidentified causes of sudden death may be due to its metabolic side-effects.

Can clozapine kill you?

A new study shows that clozapine, always thought to be a dangerous drug, actually cut the death rate among patients with schizophrenia by 26 per cent, compared with the standard treatment.

What is a fatal side effect of clozapine?

There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia.

What is the most serious potential side effect of clozapine?

Clozapine can cause serious heart problems. Call your doctor right away if you have chest pain, trouble breathing, fast or pounding heartbeats or sudden dizziness.

Does clozapine reduce life expectancy?

Abstract. Clozapine can cause severe adverse effects yet it is associated with reduced mortality risk. We test the hypothesis this association is due to increased clinical monitoring and investigate risk of premature mortality from natural causes.

What are the side effects of clozapine in schizophrenia?

Clozapine (Clozaril®, Clopine®) is an atypical antipsychotic that is effective for treatment-resistant schizophrenia. It causes agranulocytosis in up to 1% of patients 1 and regular monitoring of neutrophil counts is mandatory throughout treatment. In New Zealand one death from agranulocytosis has been reported to the IMMP.

Who are the people who have died from clozapine?

In 2018, coroners twice wrote to local NHS authorities – using so-called “reports to prevent future deaths” – after patients died while taking Clozapine. Julia MacPherson, 54, and Thomas Jackson, 24, both died in 2016.

How is clozapine related to the risk of infection?

After briefly reviewing clozapine metabolism, four major topics are discussed: (1) inflammation can increase clozapine levels; (2) clozapine can cause inflammation, particularly during titration; (3) clozapine may increase the risk of infection; and (4) more specifically, clozapine may be particularly strongly associated with the risk of pneumonia.

Is the constipation side effect of clozapine fatal?

Clozapine-induced constipation may be fatal Constipation is often regarded as a frequent, minor side effect of clozapine. However, review of New Zealand reports received by the IMMP shows that clozapine-induced constipation may be associated with serious effects such as intestinal obstruction, bowel perforation and toxic megacolon.

Is there a link between clozapine and sudden death?

Clozapine and sudden death. In accordance with our observation, at least three reports about pulmonary embolism as a complication of clozapine therapy have been published. Mortality in current and former users of clozapine. Clozapine and myocarditis. Pulmonary embolus possibly associated with clozapine treatment.

Clozapine-induced constipation may be fatal Constipation is often regarded as a frequent, minor side effect of clozapine. However, review of New Zealand reports received by the IMMP shows that clozapine-induced constipation may be associated with serious effects such as intestinal obstruction, bowel perforation and toxic megacolon.

How often does clozapine cause pulmonary embolism?

A large study 6 of mortality with clozapine which used American data found a death rate from pulmonary embolism of 30 per 100,000 person-years in users of clozapine aged 10-54 years, compared with no deaths in recent users.

Clozapine (Clozaril®, Clopine®) is an atypical antipsychotic that is effective for treatment-resistant schizophrenia. It causes agranulocytosis in up to 1% of patients 1 and regular monitoring of neutrophil counts is mandatory throughout treatment. In New Zealand one death from agranulocytosis has been reported to the IMMP.