Other

Does esomeprazole interact with clopidogrel?

Does esomeprazole interact with clopidogrel?

Concomitant use of clopidogrel and omeprazole or esomeprazole is to be discouraged unless considered essential. Doctors should check whether patients who are taking clopidogrel are also buying over-the-counter omeprazole and consider whether other gastrointestinal therapies would be more suitable.

What happens if you combine clopidogrel with omeprazole?

The results from these studies show that co-administration of clopidogrel with omeprazole results in significantly reduced exposure to the active metabolite of clopidogrel. The first randomised crossover study involved 72 healthy subjects.

Do proton pump inhibitors reduce the clinical efficacy of clopidogrel?

All PPIs are also metabolised via the cytochrome P450 system, particularly CYP2C19 and CYP3A4. All PPIs inhibit these isoenzymes to different degrees and therefore could affect the clinical efficacy of clopidogrel.

Does omeprazole interfere with Plavix?

FDA is recommending that the co-administration of clopidogrel (Plavix), a drug used to prevent blood clot formation, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid, be avoided because omeprazole reduces the effectiveness of clopidogrel.

When to call your doctor about omeprazole side effects?

Allow at least 4 months to pass before you start a new 14-day course of treatment. Call your doctor if your symptoms do not improve, or if they get worse. Some conditions are treated with a combination of omeprazole and antibiotics. Use all medications as directed. Omeprazole can affect the results of certain medical tests.

What to do if you cant swallow a capsule of omeprazole?

If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use. You must dissolve omeprazole powder in a small amount of water.

How often should I take omeprazole for erosive esophagitis?

Usual Adult Dose of Omeprazole for Erosive Esophagitis: -Patients who do not respond after 8 weeks of treatment may continue for an additional 4 weeks. -If there is a recurrence of erosive esophagitis (EE) or gastroesophageal reflux disease (GERD) symptoms, an additional 4 to 8 week course of treatment should be considered.

What happens to your bones when you take omeprazole?

osteoporosis or low bone mineral density ( osteopenia ). You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy. Ask a doctor before using omeprazole if you are pregnant or breast-feeding.

When to use omeprazole or esomeprazole with clopidogrel?

Use of either omeprazole or esomeprazole with clopidogrel should be discouraged. The current evidence does not support extending this advice to other PPIs Clopidogrel is indicated for the prevention of atherothrombotic events in patients who have had a myocardial infarction or ischaemic stroke, or who have established peripheral arterial disease.

Can a proton pump inhibitor be used with clopidogrel?

In light of the most recent evidence, the previous advice on the concomitant use of clopidogrel with proton pump inhibitors has now been modified. Use of either omeprazole or esomeprazole with clopidogrel should be discouraged. The current evidence does not support extending this advice to other PPIs

Allow at least 4 months to pass before you start a new 14-day course of treatment. Call your doctor if your symptoms do not improve, or if they get worse. Some conditions are treated with a combination of omeprazole and antibiotics. Use all medications as directed. Omeprazole can affect the results of certain medical tests.

When to use omeprazole for gastroesophageal reflux?

Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid.