Popular guidelines

Does Topamax affect male fertility?

Does Topamax affect male fertility?

Results: Long-term ingestion of Topiramate for 60 days caused a significant decrease in spermatogenesis in seminiferous tubules of the testes. Sperm motility and density were also significantly reduced in cauda epididymides and testes of the treated group.

What medications cause low sperm motility?

Certain medications. Testosterone replacement therapy, long-term anabolic steroid use, cancer medications (chemotherapy), certain antifungal and antibiotic medications, some ulcer medications, and other medications can impair sperm production and decrease male fertility.

Does morphine affect male fertility?

There were also no effects on sperm count or motility, or on the testes, seminal vesicles, and prostate weights in males after approximately 9 weeks of dosing; however, our study indicated that morphine could affect spermatogenesis and the Sertoli cell count.

What are the effects of antidepressants on sperm?

Although all animals had a decrease in LH, FSH, progesterone and testosterone, prepubertal rats were more likely to show decreased sperm membrane integrity, density, motility and morphology versus their adult counterparts. 14 This might have implications for males taking these medications beginning at young ages.

What are the effects of fluoxetine on sperm?

Fluoxetine, in particular, has been the subject of multiple studies and has been associated with gonadotoxic effects, including decreased sperm concentration and motility, increased deoxyribonucleic acid fragmentation, and decreased reproductive organ weights.

What kind of effect does citalopram have on sperm?

Citalopram has also been shown to exert toxic effects on sperm and testicles, largely through oxidative stress.

What are the effects of sertraline on sperm count?

One study examined the effects of sertraline on the reproductive system of rats treated with 5, 10 or 20 mg/kg for 4 weeks. There was a dose‐dependent increase in DNA damage (measured using the Comet assay), testicular degeneration and abnormal sperm forms, as well as a decrease in sperm count in treated animals.

What’s the best way to treat Topamax side effects?

The primary treatment to reverse symptoms is discontinuation of Topamax ® as rapidly as possible, according to the judgment of the treating physician. Other measures, in conjunction with discontinuation of Topamax ®, may be helpful.

How old do you have to be to take Topamax for seizures?

Topamax ® is indicated as adjunctive therapy for the treatment of partial-onset seizures, primary generalized tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome in patients 2 years of age and older. Topamax ® is indicated for the preventive treatment of migraine in patients 12 years of age and older.

What are the side effects of Topamax for adolescents?

The incidence of hyperammonemia (above the upper limit of normal) for adolescent patients receiving this drug for migraine prophylaxis was 26%, 14%, and 9% for doses of 100 mg, 50, mg, or placebo, respectively. Hyperammonemia with and without encephalopathy has been reported in the post-marketing period.

How much Topamax should I take for migraine headaches?

The recommended total daily dose of Topamax® as treatment for patients 12 years of age and older for prophylaxis of migraine headache is 100 mg/day administered in two divided doses (Table 3).