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What are the long term effects of neurofibromatosis?

What are the long term effects of neurofibromatosis?

Possible Complications Blindness caused by a tumor in an optic nerve (optic glioma) Break in the leg bones that does not heal well. Cancerous tumors. Loss of function in nerves that a neurofibroma has put pressure on over the long term.

Can neurofibromatosis cause death?

Conclusions: The risk of developing malignant tumors and early death is increased in patients with neurofibromatosis, the most common malignancy being malignant peripheral nerve sheath tumors.

Can neurofibromatosis be life-threatening?

NF1 is often not life-threatening. But other problems may occur over time. These may include seizures, developmental delay, and increased risk for noncancer tumors. Your child’s healthcare provider will tell you more about your child’s condition and treatment choices.

Does NF1 affect life expectancy?

Life expectancy in NF1 is approximately 8 years less than the general population. Lifetime risks for both benign and malignant tumors are increased in NF1-affected individuals.

Does NF1 run in families?

In about 50% of individuals with NF1, the disorder is inherited from a parent. Only one parent need be affected to cause a child to have NF1 (i.e. autosomal dominant disease). NF1 does not skip generations.

What are the complications of Neurofibromatosis ( NF1 )?

Complications of neurofibromatosis vary, even within the same family. Generally, complications result from tumor growth distorting nerve tissue or pressing on internal organs. Neurological problems. Learning and thinking difficulties are the most common neurological problems associated with NF1.

Is there a cure or treatment for neurofibromatosis?

There is no standard treatment for NF, and many symptoms, such as café au lait spots, do not need treatment. When treatment is necessary, options may include: What Is the Outlook for a Person With NF? The outlook for a person with neurofibromatosis depends on the type of NF they have.

How old are patients with neurofibromatosis type 1?

Neurofibromatosis type 1 (NF1) is a genetic disease with a wide range of neurological manifestations. To examine these, and to evaluate neurological morbidity in adulthood of patients with NF1, we studied a hospital-based series of 158 patients that included 138 adult patients aged >18 years and 20 children.

How does neurofibromatosis cause hearing loss in adults?

Schwannomatosis causes tumors to develop on the cranial, spinal and peripheral nerves — but rarely on the nerve that carries sound and balance information from the inner ear to the brain. Because tumors don’t usually grow on both hearing nerves, schwannomatosis doesn’t cause the hearing loss experienced by people with NF2.

Complications of neurofibromatosis vary, even within the same family. Generally, complications result from tumor growth distorting nerve tissue or pressing on internal organs. Neurological problems. Learning and thinking difficulties are the most common neurological problems associated with NF1.

What are the symptoms of neurofibromatosis in children?

Behavioral problems, such as attention deficit hyperactivity disorder (ADHD) and challenges with social skills, are commonly seen in children with NF1. Other neurological problems. Although common in all people, headaches, pain, and seizures happen more often in people with NF1. Tumors that may become cancerous.

Where does neurofibromatosis occur in the nervous system?

Neurofibromatoses are a group of genetic disorders that cause tumors to form on nerve tissue. These tumors can develop anywhere in the nervous system, including the brain, spinal cord and nerves.

Schwannomatosis causes tumors to develop on the cranial, spinal and peripheral nerves — but rarely on the nerve that carries sound and balance information from the inner ear to the brain. Because tumors don’t usually grow on both hearing nerves, schwannomatosis doesn’t cause the hearing loss experienced by people with NF2.