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What are the side effects of Depakote ER?

What are the side effects of Depakote ER?

Diarrhea, dizziness, drowsiness, hair loss, blurred/double vision, change in menstrual periods, ringing in the ears, shakiness (tremor), unsteadiness, weight changes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

What is the half life of valproate monotherapy?

Mean plasma clearance and volume of distribution for total valproate are 0.56 L/hr/1.73 m2 and 11 L/1.73 m2, respectively. Mean terminal half-life for valproate monotherapy after an intravenous infusion of 1000 mg was 16 ± 3.0 hours.

Is it safe to take valproate sodium injection?

Valproate sodium injection is contraindicated in patients with known hypersensitivity to the drug. Valproate sodium injection is contraindicated in patients with known urea cycle disorders (see WARNINGS). Hepatic failure resulting in fatalities has occurred in patients receiving valproic acid.

How much valproate should I take for dementia?

Somnolence in the Elderly. In a double-blind, multicenter trial of valproate in elderly patients with dementia (mean age = 83 years), doses were increased by 125 mg/day to a target dose of 20 mg/kg/day.

When to take valproate sodium for migraine treatment?

THIS IS ESPECIALLY IMPORTANT WHEN THE TREATMENT OF A SPONTANEOUSLY REVERSIBLE CONDITION NOT ORDINARILY ASSOCIATED WITH PERMANENT INJURY OR RISK OF DEATH (E.G., MIGRAINE) IS CONTEMPLATED. SEE WARNINGS, INFORMATION FOR PATIENTS.

Side effects of Depakote and Depakote ER can be serious and sometimes deadly. Depakote side effects include liver damage, life-threatening pancreatitis, suicidal thoughts, and blood and metabolic disorders.

When to take valproate after taking Depakote?

Cases have occurred shortly after initiation as well as several years after use. If pancreatitis is diagnosed, valproate should ordinarily be discontinued. Along with its needed effects, divalproex sodium (the active ingredient contained in Depakote) may cause some unwanted effects.

Can a food delay the absorption of Depakote?

Food can delay the absorption of Depakote (food has a more significant effect on the tablets compared with the sprinkles). It may take several weeks of regular dosing before an effect on mood or seizure frequency is reported. Depakote (Divalproex sodium delayed-release tablets) [Package Insert] Revised 11/2018.

Can a low dose aspirin be taken with Depakote?

People taking low-dose aspirin can continue taking it with Depakote, but some of the other common prescription and over-the-counter drugs, however, have moderate interactions with Depakote. A moderate interaction can make side effects worse and decrease a medicine’s success rate.

What side affects are there from Depakote?

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    Are there long-term side effects from Depakote?

    Common side effects of Depakote include: abdominal pain, asthenia, dizziness, drowsiness, nausea, and anorexia. Other side effects include: abnormality in thinking, alopecia, ataxia, nystagmus disorder, tremor, weight loss, fever, and skin rash. See below for a comprehensive list of adverse effects.

    What are Depakote er rare side effects?

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    • loss of consciousness.

      What are the benefits of Depakote?

      Benefits of Depakote. Depakote® (divalproex sodium) is an antipsychotic medication that is often prescribed for the prevention of migraines and the treatment of epileptic seizures and manic episodes.

      When to call your doctor about Depakote toxicity?

      Risk of serious liver damage is more likely to occur within the first 6 months of treatment, and may continue despite discontinued use of the drug. Call your doctor right away if you experience any of the following symptoms: Inflammation of your pancreas that can cause death.

      Can a 2 year old die from Depakote?

      Serious liver damage that can cause death, especially in children younger than 2 years old. Risk of serious liver damage is more likely to occur within the first 6 months of treatment, and may continue despite discontinued use of the drug. Call your doctor right away if you experience any of the following symptoms:

      What are the side effects of taking Depakote ER?

      Depakote ER. Call your doctor at once if the person taking this medicine has signs of liver or pancreas problems, such as: loss of appetite, upper stomach pain (that may spread to your back), ongoing nausea or vomiting, dark urine, swelling in the face, or jaundice (yellowing of the skin or eyes).

      People taking low-dose aspirin can continue taking it with Depakote, but some of the other common prescription and over-the-counter drugs, however, have moderate interactions with Depakote. A moderate interaction can make side effects worse and decrease a medicine’s success rate.

      How long does it take for Depakote sprinkles to take effect?

      Response and effectiveness The time it takes for Depakote to reach its peak effects depends on the formulation used. Tablets take 4 hours to reach a peak, Depakote sprinkles take just over three. Food can delay the absorption of Depakote (food has a more significant effect on the tablets compared with the sprinkles).

      How old do you have to be to take Depakote ER?

      Depakote ER tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. This medicine tablets are sometimes used together with other seizure medications. Depakote ER tablets are also used in adults to prevent migraine headaches, or to treat manic episodes related to bipolar disorder (manic depression).

      Is there a cure for hepatoxicity from Depakote?

      Hepatoxicity is an inflammation of the liver. It is a serious condition that can be fatal. There is no treatment, cure or reversal for liver damage. The primary treatment is to discontinue any medications processed through the liver and to avoid alcohol. Doctors may prescribe medications that help to reduce the symptoms of liver damage.

      What are the most common side effects of Depakote?

      Q: What are the most common side effects experienced with Depakote? A: Common side effects experienced with Depakote include drowsiness, nausea, abdominal pain, diarrhea, vomiting, low platelet count, tremors, tiredness, and hair loss. The side effects may be mild to moderate, but they may also be signs of a more serious condition.

      What’s the maximum dose of Depakote ER you can take?

      Simple and Complex Absence Seizures. The recommended initial dose is 15 mg/kg/day, increasing at one week intervals by 5 to 10 mg/kg/day until seizures are controlled or side effects preclude further increases. The maximum recommended dosage is 60 mg/kg/day.

      Are there any black box warnings on Depakote?

      There are currently three black-box warnings required to be placed inside the Depakote package insert. These warnings receive their name from the black box surrounding the text of the warning.

      Risk of serious liver damage is more likely to occur within the first 6 months of treatment, and may continue despite discontinued use of the drug. Call your doctor right away if you experience any of the following symptoms: Inflammation of your pancreas that can cause death.