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What does COMT mutation mean?

What does COMT mutation mean?

The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. An estimated 20-30% of Caucasians of European ancestry have a COMT gene variation which limits the body’s ability to remove catechols (a specific type of molecule that includes dopamine, norepinephrine, estrogen, etc.)

What is COMT val val?

The patients who have the overactive enzyme are homozygous for valine form (Val/Val), which renders COMT hyper-efficient and may result in dopamine deficiency. In contrast, genotype Met/Met results in a hypo-active enzyme and causes excessive dopamine in the synaptic cleft.

How is COMT mutation treated?

If you have the COMT Val/Val variant you may benefit from being treated with stimulants, and by including flavonoids (red wine, berries, apples), and Quercetin (red wine, berries, cherries, leafy veggies) in your diet.

What is MTHFR COMT?

The Catechol-O-methyltransferase (COMT) is involved in the pain signaling pathway and can help predict pain tolerance. Catechol-dependent functions can include- cardiovascular, cognitive, and pain processing. Aids in breaking down- Catecholamine Neurotransmitters: dopamine, epinephrine, and norepinephrine.

What is a normal COMT gene?

Normal Function The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. Two versions of this enzyme are made from the gene. The longer form, called membrane-bound catechol-O-methyltransferase (MB-COMT), is chiefly produced by nerve cells in the brain.

What is normal COMT gene?

Does everyone have the COMT gene?

Everyone carries two copies of the COMT gene, one inherited from each parent. The study showed that people with two copies of the “met” form of the COMT gene had a much more pronounced response to pain than those who carried two copies of the “val” form of the gene.

Is being a worrier genetic?

Researchers at Yale have identified a gene mutation for “rumination” — the kind of chronic worry in which people obsess over negative thoughts. It’s a variation of a gene known as BDNF that’s active in the hippocampus, an area of the brain involved in thinking and memory.

What does COMT gene do?

The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. Two versions of this enzyme are made from the gene. The longer form, called membrane-bound catechol-O-methyltransferase (MB-COMT), is chiefly produced by nerve cells in the brain.

How do you get tested for MTHFR?

A doctor may recommend running a blood test to check a person’s homocysteine levels. Although it is possible to identify an MTHFR gene mutation through genetic testing, organizations such as the American Heart Association recommend against screening for common MTHFR gene variants in regards to cardiovascular risk.

Is COMT a gene?

Is the COMT Valine polymorphism related to MTHFR?

Be forewarned: symptoms that you might associate with MTHFR malfunction may actually be due to COMT malfunction. The COMT valine polymorphism (associated with lower dopamine and lower cognitive function) has been associated with apathy and depression.7 In this case, the lower dopamine is caused by high metabolism, not low production.

What happens if you have both COMT and MTHFR mutations?

If you have both COMT and MTHFR mutations, you are at an increased risk for feeling stressed and anxious. MTHFR mutations create a methylation deficiency. Methylation is essential for many body processes such as healthy neurotransmitter production and breakdown.

Why are Val / Met allele carriers more irritable?

Heterozygous Val/Met allele carriers exhibit an intermediate enzyme activity. Dopamine and epinephrine help to create alertness and attention and people with COMT gene mutations tend to get more irritable. Individuals with a COMT gene mutation are generally volatile susceptible to depression, anxiety, mood disorders and toxicity symptoms.

What happens to the COMT gene in v158m?

COMT helps the body get rid of excess Dopamine, Epinephrine, Norepinephrine and Estrogens. A homozygous mutation of the V158M allele is associated with a 40% reduction in COMT gene activity.

Be forewarned: symptoms that you might associate with MTHFR malfunction may actually be due to COMT malfunction. The COMT valine polymorphism (associated with lower dopamine and lower cognitive function) has been associated with apathy and depression.7 In this case, the lower dopamine is caused by high metabolism, not low production.

How are genetic variants related to the MTHFR gene?

MTHFR tells our body how to create an enzyme involved in breaking down the amino acid homocysteine. As is true for any gene, the DNA code of the MTHFR gene can vary. When we identify a part of the sequence that varies, we call it a “variant.” Genetic research aims to identify specific variants that cause harm or benefit to health.

How are MTHFR and COMT mutations related to anxiety?

With COMT mutations, you experience slower breakdown speeds of neurotransmitters, and with MTHFR mutations your body is producing less neurotransmitters or is unable to properly breakdown neurotransmitters. Having a combination of both of these mutations results in a predisposition to anxiety.

Heterozygous Val/Met allele carriers exhibit an intermediate enzyme activity. Dopamine and epinephrine help to create alertness and attention and people with COMT gene mutations tend to get more irritable. Individuals with a COMT gene mutation are generally volatile susceptible to depression, anxiety, mood disorders and toxicity symptoms.