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What does high alkaline phosphatase in the blood mean?

What does high alkaline phosphatase in the blood mean?

What Does High Alkaline Phosphatase Mean? The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Children and pregnant women can have significantly higher levels of the enzyme in their blood [ 1 ]. Values above 130 U/L are usually considered to be high.

How is bone alkaline phosphatase related to Paget’s disease?

Paget’s disease is a common disorder that affects bone strength and formation. Abnormally high levels of bone alkaline phosphatase can be an indicator of bone turnover, so while the enzyme does not cause the disease, it can be a helpful indicator [ 23 ].

Do you need to fast before an alkaline phosphatase test?

You don’t need any special preparations for an alkaline phosphatase test. If your health care provider has ordered other blood tests, you may need to fast (not eat or drink) for several hours before the test.

Can a birth control pill increase alkaline phosphatase?

Birth control pills can increase alkaline phosphatase to many times the level of a normal range [ 8 ]. Exercise increases bone alkaline phosphatase levels after thirty and fifty minutes of moderate to intensive exercise in male cyclists, but it quickly returns to normal [ 9 ].

How does an alkaline phosphatase blood test work?

ALP blood test measures blood alkaline phosphatase to detect liver and bone problems. It is ordered by the doctor if the patient has symptoms of liver or bone diseases. The signs and symptoms of liver disease include itching, dark urine, light colored feces, jaundice, abdominal swelling and pain, nausea,…

Where is high alkaline phosphatase found in children?

High Alkaline Phosphatase in Children. Alkaline phosphatase is an enzyme that can be found in many of the body’s tissues, but its highest concentration is inside bone and liver cells and in the bile ducts. It is a useful test to evaluate childhood liver and bone conditions, especially in conjunction with other tests,…

How is alkaline phosphatase related to sickle cell anemia?

Sickle cell anemia is associated with high levels of alkaline phosphatase. The higher alkaline phosphatase levels correlate with worsened bone and other tissue damage in sickle cell anemia patients [ 27, 28 ].

What does high alkaline phosphatase mean for colon cancer?

Alkaline phosphatase levels are frequently high in patients with metastatic colon cancer. Increasing alkaline phosphatase levels are correlated with an increased cancer stage and may indicate that cancer has spread to the liver [ 18 ]. 9) Breast Cancer