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What is DCIS with Comedonecrosis?

What is DCIS with Comedonecrosis?

A comedo-type ductal carcinoma in situ, also known as comedocarcinoma in situ is the high grade subtype of ductal carcinoma in situ (DCIS). It completely fills and dilates the ducts and lobules in TDLU with plugs of high grade tumor cells with central necrosis “comedonecrosis”.

What does intermediate nuclear grade mean?

A term used to describe how abnormal cancer cells look under a microscope. Intermediate-grade cancer cells look more abnormal than low-grade cancer cells but not as abnormal as high-grade cancer cells.

What is Comedonecrosis?

Specialty. Oncology. Comedocarcinoma is a kind of breast cancer that demonstrates comedonecrosis, which is the central necrosis of cancer cells within involved ducts. Comedocarcinomas are usually non-infiltrating and intraductal tumors, characterized as a comedo-type, high-grade ductal carcinoma in situ (DCIS).

What is intermediate grade ductal carcinoma ( DCIS )?

DCIS that is intermediate grade, is nuclear grade 2, or has an intermediate mitotic rate falls in between these two. Patients with higher grade DCIS may need additional treatment.

What is comedo type ductal carcinoma in situ?

Comedo type ductal carcinoma in situ. Casting-type microcalcifications are the most frequent mammographic finding (78% of cases) in comedotype DCIS. Histologically DCIS-comedo is diagnosed when at least one duct in the breast is filled and expanded by large, markedly atypical cells. It has the risk of occult infiltration. A comedo…

What is apocrine ductal carcinoma in situ ( ADCIS )?

Apocrine ductal carcinoma in situ of the breast: histologic classification and expression of biologic markers Apocrine ductal carcinoma in situ (ADCIS) has been called a special type of ductal carcinoma in situ (DCIS) because the histologic grading is considered difficult using the classification schemes that have been proposed for common DCIS.

What does a pathology report say about ductal carcinoma?

Understanding Your Pathology Report: Ductal Carcinoma In Situ (DCIS) When your breast was biopsied, the samples taken were studied under the microscope by a specialized doctor with many years of training called a pathologist. The pathologist sends your doctor a report that gives a diagnosis for each sample taken.

DCIS that is intermediate grade, is nuclear grade 2, or has an intermediate mitotic rate falls in between these two. Patients with higher grade DCIS may need additional treatment.

Comedo type ductal carcinoma in situ. Casting-type microcalcifications are the most frequent mammographic finding (78% of cases) in comedotype DCIS. Histologically DCIS-comedo is diagnosed when at least one duct in the breast is filled and expanded by large, markedly atypical cells. It has the risk of occult infiltration. A comedo…

What kind of cancer is high grade ductal carcinoma?

Three sites of calcifications were biopsied. The posterior site showed high–nuclear grade ductal carcinoma in situ (DCIS) with comedonecrosis. The DCIS specimen stained positive for estrogen receptor (3+, 90%) and progesterone receptor (3+, 75%).

What are the risk factors for ductal carcinoma in situ?

Factors that may increase your risk of DCIS include: Increasing age. Personal history of benign breast disease, such as atypical hyperplasia. Family history of breast cancer. Never having been pregnant. Having your first baby after age 30.