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What is meant by adenocarcinoma of the prostate?

What is meant by adenocarcinoma of the prostate?

Adenocarcinoma is the type of cancer that develops in gland cells. It is the most common type of cancer found in the prostate gland.

Can a prostate adenocarcinoma be detected by Dre?

Currently, most prostate carcinomas are clinically detected by serum PSA screening and by DRE, not by clinical symptoms. Prostatic adenocarcinoma ( Fig. 7.34) may yield cells in voided urine spontaneously or after prostatic massage, particularly when the carcinoma is high grade.

What can be found on a prostate biopsy that is benign?

Focal atrophy can sometimes look like prostate cancer under the microscope. Atypical adenomatous hyperplasia (which is sometimes called adenosis) is another benign condition that can sometimes be seen on a prostate biopsy. Finding any of these is not important if prostate cancer is also present.

How is the prostate biopsy done at Mayo Clinic?

The ultrasound images are also used to guide the prostate biopsy needle into place. Once the area is numbed and the biopsy device is situated, your doctor will retrieve thin, cylindrical sections of tissue with a spring-propelled needle.

How is the diagnosis of prostatic adenocarcinoma made?

Most prostatic adenocarcinomas are composed of acini arranged in one or more patterns. The diagnosis relies on a combination of architectural and cytologic findings. The light microscopic features are usually sufficient for diagnosis, but rare cases may benefit from immunohistochemical studies ( Table 32-10 ). TABLE 32-10.

Focal atrophy can sometimes look like prostate cancer under the microscope. Atypical adenomatous hyperplasia (which is sometimes called adenosis) is another benign condition that can sometimes be seen on a prostate biopsy. Finding any of these is not important if prostate cancer is also present.

Can a prostate biopsy detect prostate cancer without PNI?

One study followed 381 men undergoing radiation therapy for localized prostate cancer, 86 (23%) of whom were found to have PNI on prostate biopsy. After 5 years of follow up, 69% of men without PNI were free of cancer as compared to only 47% of men with PNI.

Can a prostate biopsy show that cancer has left the gland?

This does not mean that the cancer has left the gland. Not withstanding this the importance of this finding , it takes on a new light when you realize that nerves within the prostate travel outside of the gland through microscopic holes in the prostate capsule.

Can a high grade PIN turn into prostate cancer?

High-grade prostatic intraepithelial neoplasia (high-grade PIN) is considered a pre-cancer of the prostate, because it can turn into prostate cancer over time. Still, the risk of prostate cancer linked to high-grade PIN is lower than the risk of prostate cancer seen with findings atypical or suspicious for cancer.