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When should I stop taking hydralazine?

When should I stop taking hydralazine?

You should not use hydralazine if you are allergic to it, or if you have: coronary artery disease; or. rheumatic heart disease affecting the mitral valve.

How long does it take for hydralazine to get in your system?

Hydralazine is rapidly absorbed after oral administration, and peak plasma levels are reached at 1-2 hours. Plasma levels of apparent hydralazine decline with a half-life of 3-7 hours. Binding to human plasma protein is 87% Plasma levels of hydralazine vary widely among individuals.

Can you just stop taking hydralazine?

Don’t stop taking hydralazine suddenly. Doing so may lead to uncontrolled high blood pressure. This can put you at a higher risk for heart problems, such as chest pain or a heart attack. If you need to stop taking this drug, your doctor will slowly decrease your dose over two weeks.

How often should I take hydralazine hydrochloride therapy?

Initiate therapy in gradually increasing dosages; adjust according to individual response. Start with 10 mg four times daily for the first 2-4 days, increase to 25 mg four times daily for the balance of the first week. For the second and subsequent weeks, increase dosage to 50 mg four times daily.

How long does hydralazine stay stable in the body?

The 10 mg/mL Hydralazine HCl room temperature samples compounded in Versa FreeTM, 70% Sorbitol Solution, and Versa FreeTMwith 1% Carrageenan were also stable for at least 63 days. KEYWORDS: Hydralazine Hydrochloride, Versa FreeTM, Humco, Sorbitol 70%, Oral Solution, Pediatric Use INTRODUCTION:

What is the molecular weight of hydralazine hydrochloride?

Hydralazine hydrochloride USP is a white to off-white, odorless crystalline powder. It is soluble in water, slightly soluble in alcohol, and very slightly soluble in ether. It melts at about 275°C, with decomposition, and has a molecular weight of 196.64.

How does hydralazine work in the cardiovascular system?

Although the precise mechanism of action of hydralazine is not fully understood, the major effects are on the cardiovascular system. Hydralazine apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle.

How often should you take hydralazine as an adult?

Adult dosage (ages 18–64 years) Starting dosage: 10 mg taken by mouth 4 times per day for 2–4 days Dosage adjustments: Your doctor may slowly increase your dose up to 50 mg taken 4 times per day.

How long is the half life of hydralazine?

Hydralazine is rapidly absorbed after oral administration, and peak plasma levels are reached at 1-2 hours. Plasma levels of apparent hydralazine decline with a half-life of 3-7 hours.

What kind of powder is hydralazine hydrochloride USP?

Hydralazine hydrochloride USP is a white or almost white, crystalline powder. It is soluble in water, slightly soluble in ethanol (96%), and very slightly soluble in methylene chloride. It melts at about 273°C, with decomposition. Each tablet for oral administration contains 10 mg, 25 mg, 50 mg or 100 mg hydralazine hydrochloride, USP.

Are there any side effects to taking hydralazine?

Hydralazine side effects. lupus -like syndrome–joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color. Common side effects may include: