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Why does rhabdomyolysis occur with statins?

Why does rhabdomyolysis occur with statins?

Rhabdomyolysis is a well-documented side effect of statin therapy. This risk is increased with concurrent use of medications that inhibit cytochrome p450-3A4 (CYP3A4), such as macrolide antibiotics.

Does atorvastatin cause rhabdomyolysis?

Simvastatin was the most common statin medication reported in association with rhabdomyolysis (55 cases), most commonly taken at a dose of 40 mg/day. Atorvastatin was the second most common drug (20 cases), used in doses of 10 mg/day.

Why do statins increase CK?

A rare but worrisome side effect of taking a cholesterol-lowering statin is the breakdown of muscle tissue. To guard against it, people who take statins have often been advised to have regular blood tests to spot rising levels of creatine kinase (CK), a byproduct of muscle breakdown.

What medications when taken along with statins most increase the risk of rhabdomyolysis?

The higher the dose of statins, the higher the risk of rhabdomyolysis becomes. The risk also increases if certain drugs — including cyclosporine (Sandimmune) and gemfibrozil (Lopid) — are taken in combination with statins.

Can you recover from rhabdomyolysis?

Many people recover after rhabdomyolysis treatment. But most people have lingering muscle weakness for a few weeks after the injury. In up to 50% of rhabdomyolysis cases, people experience acute kidney injury. Some people need dialysis for an extended time if their kidneys cannot function.

What are the effects of statin induced rhabdomyolysis?

Mechanism of statin-induced rhabdomyolysis Statins, a group of drugs used for the treatment of hypercholesterolemia, have adverse effects on skeletal muscle. The symptoms of these effects range from slight myalgia to severe rhabdomyolysis. The number of patients currently taking statins is estimated to be several millions worldwide.

What causes severe muscle pain after taking statins?

This intense pain may be a symptom of rhabdomyolysis (rab-doe-my-OL-ih-sis), a rare condition that causes muscle cells to break down. The most common signs and symptoms of rhabdomyolysis include: Severe muscle aching throughout the entire body The higher the dose of statins, the higher the risk of rhabdomyolysis becomes.

What are the symptoms of statin induced myopathy?

The clinical spectrum of statin induced myopathy range from myalgia, myositis, rhabdomyolysis to asymptomatic increase in the blood levels of creatine kinase. Symptoms include fatigue, muscle pain, muscle tenderness, muscle weakness, nocturnal cramping and tendon pain.2 The muscle symptoms tend to be proximal, generalized and worsen with exercise.

What kind of drugs can cause rhabdomyolysis?

Statin medications can also lead to rhabdomyolysis, especially in people who have diabetes or liver disease. Illegal drugs and alcohol: Heroin, LSD, cocaine, and excessive alcohol are toxic to the body and can cause muscles to deteriorate.